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However, histamines are most well-known for triggering inflammatory responses when potential invaders enter your body

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Wu D, Liu J, Zhou C, Ma W, Zhou L, Ge Y, et al

Intriguingly, recent investigations have demonstrated that irisin upregulates the expression of TFAM (mitochondrial transcription factor A) through the activation of the SIRT1/PGC-1 signaling pathway, thereby enhancing mitochondrial metabolism and mitigating microglial activation 18

10.1038/srep38211 77 HollerN.ZaruR.MicheauO.ThomeM.AttingerA.ValituttiS.et al (2000)