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Nicotinamide N-methyltransferase (NNMT) is an enzyme that plays a crucial role in cellular metabolism and energy homeostasis

Stereoselection controlled by electronic effect of a carbonyl group in oxidation of NAD(P)H analog

This method is often used for patients who need injections often or have less muscle mass

This does not establish treatment of human liver disease

SLU-PP-332 is a first-in-class small molecule designed to function as an "exercise mimetic." Developed through a collaboration between Saint Louis University and Washington University, it acts as a potent pan-agonist of the Estrogen-Related Receptor (ERR) family