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CSD is closely associated with migraine aura but is also observed in cerebral ischemia, epilepsy, and traumatic brain injury (10)

One way to increase cellular levels is by ingesting N-acetylcysteine (NAC) which is absorbed from the digestive tract and releases cysteine in the bloodstream

However, this binary classification has faced recent criticism ( In contrast, M2 macrophages, induced by IL-4, IL-13, IL-10, or glucocorticoids, produce anti-inflammatory cytokines, primarily TGF- and IL-10 ( Figure 6 ) ( Figure 6 This advanced classification provides a framework for understanding the diverse roles of macrophages in regulating ferroptotic

doi: 10.1007/s00394-014-0706-z

Although the evidence has reached an overwhelming level and was recently reviewed in detail, controversy persists