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Studies of embryos created through IVF illustrate the scale of this decline: if you're in your early 20s, roughly 20% of your eggs carry chromosomal abnormalities, rising to about 40% by age 35, roughly 60% by age 40, and over 80% by age 43. These chromosomal errors, most commonly aneuploidy, are the primary reason that fertility declines with age, that miscarriage rates increase, and that conditions such as Down syndrome become more common in pregnancies conceived later in life