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Glutathione - Synthesis SFRBM Education Program Dickinson et al.13 de novo synthesis - 7 Glycine -glutamylcysteinylglycine -glutamylcysteine (GSH) GSH synthase ATP ADP Glutathione - Synthesis SFRBM Education Program Dickinson et al.14 Glutathione breakdown 1 The linkage of glutamate to cysteine via the gamma carbon makes GSH refractory to standard proteases

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