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Every documented case of semaglutide-associated allodynia has resolved either with medication discontinuation, dose reduction, or spontaneously over weeks to months while continuing the medication

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More precisely, we investigated whether effects were driven by either an increase in parasympathetic nervous system (PNS) activity or a decrease in sympathetic nervous system (SNS) activity, as both can lead to enhanced insulin secretion 21 (Supplementary Fig

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Its clinical relevance lies in addressing the circulatory imbalance that drives renal failure in cirrhosis, rather than acting directly on the kidneys themselves

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