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They're built into how the La Grange clinic runs every day, Sunday through Saturday
The metabolic changes come from cellular-level effects rather than artificially elevated sympathetic tone
The 28 days comes from USP and CDC, applied to the whole multi-dose vial category
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[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses
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