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Collaboration between different healthcare professionals, such as endocrinologists, primary care physicians, and gynecologists or urologists, may be beneficial in managing complex cases

this should be considered by clinicians in any trial or supervised setting, in line with NICE guideline NG28 (Type 2 diabetes in adults)

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In addition to the PI3K-Akt axis, the insulin IRS complex can activate the MAPK signaling pathway through the Shc-Grb2-SOS-Ras-Raf-MEK-ERK cascade, participating in proliferative effects such as cell proliferation and protein synthesis (77)

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