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Preclinical models demonstrate that GIPR activation in the hypothalamus may contribute to reduced food intake and improved energy balance [41,42]
The effect is dose-dependent and typically strongest during the first injection or oral dose
The two embryos with reduced PGC numbers were independently targeted at distinct genes, yet other embryos targeted at the same genes exhibited normal PGC numbers (Supplementary information, Table S3), suggesting potential off-target effects
Additionally, donors should inform staff about their diabetes management status if applicable, including stability of blood glucose levels, frequency of monitoring, and history of hypoglycemic episodes
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