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While RSL3 promotes ferroptosis via inhibition of GPX4, it also appears to enhance tumor cell DNA damage
The first weeks on medication bring significant adjustment
In XIGDUO XR-treated patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct the acidosis and remove accumulated metformin (metformin HCl is dialyzable, with a clearance of up to 170 mL/min under good hemodynamic conditions)
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