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Acknowledgements This research was funded by the Swedish Research Council (20142945 to KPS and 20137107 to PR), Novo Nordisk Foundation Excellence project grant (to KPS), Ragnar Sderberg Foundation (to KPS), Harald Jeanssons Stiftelse and Greta Jeanssons Stiftelse (to KPS), Magnus Bergvalls Stiftelse (to KPS), Wallenberg Foundation and Center for Molecular and Translational Medicine (to KPS) and National Institute of Health NIH-DK096139 (to MRH) and NIH-DK104897 (to SEK)

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