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Similarly, in aged rodents, both intranasal and intramuscular administration of Epitalon led to elevated IL-2 expression specifically in certain hypothalamic nuclei [49]

Vitamin B12 deficiency can cause fatigue, weakness, anemia, and dizziness

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Yes, with a clear dose-response relationship: 0.25 mg dose: 9-11% constipation rate 0.5 mg dose: 12-14% constipation rate 1.0 mg dose: 15-18% constipation rate 2.4 mg dose: 23-24% constipation rate The increase from 0.5 mg to 2.4 mg roughly doubles the constipation risk

This study was designed to systematically investigate the cartilage-protective effects of AOD9604, both alone and in combination with HA, using a well-established collagenase-induced OA rabbit model