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Clinical guidelines recommend a dose escalation of a minimum every 4 weeks to minimize gastrointestinal adverse reactions

Therapeutic Advances in Drug Safety, 2 (3), 113-128

If nausea limits fluid intake, try small, frequent sips throughout the day, or consume ice chips or frozen fruit

Healthcare providers can assess whether the reactions represent true allergic phenomena versus irritant reactions, which have different management implications and may affect decisions about treatment continuation

In addition, recent findings have indicated that GLP-1 agonists, such as liraglutide have therapeutic potential in preventing inflammation-related disorders through the regulation of protein kinase A (PKA)/ cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) signals