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The observed results always depend on the model used, the experimental design, the concentration of the compound, the duration of exposure, and the selected analytical parameters

In rat and human tissue, high signals for GHSR1a mRNA are found expressed in several hypothalamic nuclei, the pituitary, and the dentate gyrus of the hippocampus, with additional yet reduced signals in CA2 and CA3 of the hippocampus, the substantia nigra, the ventral tegmental area, and the median raphe nuclei (Guan et al., 1997

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In fact, uncontrollable food eating behaviors can generate their own unique type of mental health concerns