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2 The immunotherapeutic landscape of osteosarcoma: challenges and resistance mechanisms 2.1 The immunosuppressive TME The osteosarcoma TME is a complex ecosystem comprising malignant cells, stromal cells, immune infiltrates, and ECM components embedded within a mineralized bone scaffold (9, 22)

Dosages in animal studies: In the vast majority of preclinical studies, the doses used in rats range between 10 g/kg and 10 ng/kg of body weight, administered intraperitoneally or orally

A: L-Glutathione, Vitamin-C, and Alpha Lipoic Acid Tablet should be stored in a dry and cool place