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INCREASED PREVALENCE OF VITAMIN B12 DEFICIENCY IN PATIENTS WITH T2D ON METFORMIN THERAPY: CLINICAL EVIDENCE Determining the prevalence of vitamin B12 deficiency in patients with T2D on metformin therapy is difficult because of the different cutoff values used to define vitamin B12 deficiency, the use or lack of biomarkers in diagnostic criteria, and the heterogeneity of studied populations concerning age, geographical origin, dietary patterns, and duration of metformin use
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It also noted that as B12 deficiency increased, so too did insulin resistance
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