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This work was supported by the National Institutes of Health (ES032473 and AI167884)
Initial treatments may require several injections per week, followed by maintenance doses every month
In the Phase 2 trial, participants on the 12mg dose of retatrutide lost up to 24.2% of their body weight over 48 weeks
Vascular endothelial growth factor receptor 1 (interpreted as sFlt-1), quantified by two SOMAmers, was also released from the placenta to the maternal circulation, with a 3335% higher level in the uterine vein as compared to the radial artery (Additional file 2: Table S3)
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