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Chem Res Toxicol
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(iv) the 2-oxoadipate dehydrogenase complex that catalyzes the decarboxylation of 2-oxoadipate to glutaryl-CoA in the catabolic pathway of lysine, hydroxylysine, and tryptophan
Notably, recent research suggests this relationship is bi-directional: aging causes circadian/sleep disruption, and conversely, circadian disruption can accelerate aspects of aging ( Given these insights, there is intense interest in identifying interventions that can stabilize or strengthen circadian rhythms in older people
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Rashighi, M
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