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Dose escalation phases require additional adjustment

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Bax oligomerization is associated with the formation of openings in the OMM to allow the release of cytochrome c and other IMS proteins into the cytosol, and hence Bax oligomerization is considered a critical regulatory point in cell death (Youle and Strasser, 2008)

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doi.org/10.1056/NEJMoa2032183

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But, its vital to note the difference between animal studies and human health

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They have been shown to be effective in reducing body weight, improving insulin resistance, and reducing other metabolic abnormalities in women with PCOS

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