Weight loss injections like GLP-1 medications have become a popular treatment for weight management in people living with obesity or those who are overweight with related health conditions
Journal of Dietary Supplements, 18 (1), 116
It is especially beneficial for obese pets and those with dilated cardiomyopathy (DCM)
Pharmacokinetics: Cyanocobalamin is administered intranasally, orally, and parenterally, while hydroxocobalamin is administered only parenterally. Once absorbed, vitamin B12 is highly bound to transcobalamin II, a specific B-globulin carrier protein and is distributed and stored primarily in the liver as coenzyme B12. The bone marrow also stores a significant amount of the absorbed vitamin B12. This vitamin crosses the placenta and is distributed into breast milk. Enterohepatic recirculation conserves systemic stores. The half-life is about 6 days (400 days in the liver). Elimination is primarily through the bile; however, excess cyanocobalamin is excreted unchanged in the urine
Moreover, HGF overexpression attenuates monocyte chemoattractant protein-1 (MCP-1) induction, predominantly in astrocytes, thus reducing accumulation of activated microglia (Kadoyama et al., 2007)
