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Cellular Effects in Experimental Models In laboratory and preclinical models, DSIP demonstrates a range of observable effects across neural and endocrine systems

A class-level NMA was conducted to estimate the incremental benefit of tirzepatide and GLP-1RAs over placebo, and an agent-level NMA was conducted to explore differences between tirzepatide and individual GLP-1RA agents

This dual action on GLP-1 and GIP receptors is why tirzepatide often outperforms single-pathway medications in clinical head-to-head comparisons

At GLP-1R and GIPR, EC50 values for cAMP accumulation are in the low nanomolar to picomolar range