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It also prevented weight gain and hypoglycemia, which are often associated with sulfonylurea drugs (Huyen 2012)
GLP-1 medications use gradual dose escalation protocols, increasing every four weeks to minimize side effects, which means the full therapeutic dose may not be reached until 16 to 20 weeks
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The anti-inflammatory mechanisms of GLP-1RAs include that they can reduce inflammation through inhibition of nuclear factor kappa B (NF-B) signalling, can reduce proinflammatory cytokine signalling (these cytokines are also released by mast cells), and can modulate immune cell activity
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