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Conversely, high levels of glutathione in the body have been linked to the development of chemotherapy resistance in cancer patients

Overdose may affect the effect of chemotherapy

These were also detected in our study by western blot assay, further proving the alteration of glycolysis in PC tumorigeneses

Disulfide-linked polymerdrug conjugates and nanocarriers engineered for GSH-triggered drug release have shown favorable safety and preliminary efficacy profiles, highlighting the feasibility of translating redox-responsive strategies into clinical practice [120]