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Not only are newer orals like orforglipron less expensive to produce because they dont include devices, like prefilled syringes or injectors, but orforglipron isn't a protein-based molecule
Yet both groups reported gastrointestinal problems at nearly identical rates (around 60-70%)
Mayo Clinic plastic surgery fellowship
A meta-analysis of large randomized controlled trials examining the association between incretin-based therapies and AP revealed an 82% (95% CI, 1.172.82) higher likelihood of developing AP when using these drugs compared to conventional therapy (Roshanov and Dennis, 2015)
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