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Arteries and veins lose their elasticity, leading to increased vascular stiffness, which can result in higher blood pressure and a higher risk of cardiovascular diseases
10.1007/s10815-014-0425-7 27
CYP2E1 is a well-known leaky enzyme (due to the constitutive high spin form of this enzyme) with a unique ability to produce ROS and other radical intermediates during the catalytic cycle (Harjumaki et al
They are also reviews, not new trials, and their author had a long commercial association with the compounds development
However, while vitamin B12 appears to be generally safe, more is not necessarily better
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