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[18] [19] As you lose substantial amounts of fat, particularly subcutaneous fat beneath the skin, your body's natural insulation decreases, making you more susceptible to feeling cold in environments that previously felt comfortable

Phase 2 and Phase 3 trials are expected to report results over the next two to four years, and regulatory discussions about potential addiction indications are already beginning

Weight loss typically begins within the first 12 weeks as appetite decreases and water retention drops

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