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Other than bariatric surgery, which is not without significant risks, or eating less and moving more, which doesnt suit everyone, there is very little in the way of reliable medical treatments for obesity

Increased intake of nitrosamines, which are known carcinogens, may be one of a number of dietary and environmental factors that contributes to the development of esophageal cancer in residents of high-risk regions

Insurance implications: Most plans wont cover off-label use

Essentially, it shields the brain from toxins and pathogens that could cause harm while simultaneously facilitating the entry of vital substances like glucose and specific hormones crucial for brain health and function, governed partly by the capillary endothelial cells

If you want the biology the literature predicts , deliver the molecule the way the literature says works