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1 H-fMRS spectra were acquired continuously for a 5-min baseline period and during the initial 30 min of the ketamine infusion using point resolved spectroscopy, with chemical selective suppression for water suppression and outer volume suppression with very selective suppression pulses (TR = 2,000 ms, TE = 40 ms, 8-step phase cycle, 1,040 transients out of 16 water unsuppressed transients) (Fig

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GSH biosynthesis occurs exclusively in the cytosol via a two-step ATP-dependent reaction catalysed sequentially by two enzymes: gamma-glutamylcysteine synthetase (GCL also referred to as gamma-glutamylcysteine ligase, comprising the catalytic GCLC subunit and regulatory GCLM subunit), which catalyses the rate-limiting first step of joining glutamate and cysteine

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68% of patients reporting any energy benefit place the onset here