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In a recent study, Tan and coworkers engineered and expressed two GLP-1 analogues by genetically fusing a modified GLP-1 (Ala8Gly) to one or two tandem HSA-binding DARPins through a (GGGGS) 3 flexible linker
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The stable clone (cells over expressing GPx1) in comparison to wild type (cells expressing basal GPx1) showed enhanced tolerability against hydroperoxide (750 M)-induced cell death
scientists quickly discovered their potential beyond blood sugar control
Use the abdomen, thigh, or back of the upper arm for injection sites, rotating locations each week to minimize lipodystrophy (changes in fat distribution under the skin)
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