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Intranasal delivery bypasses the gastrointestinal tract and hepatic first-pass metabolism, offering a higher degree of bioavailability and more predictable absorption curves

Who May Be at Greater Risk of Adverse Effects Over Time Older adults, people with prior pancreatitis or gallbladder disease, those with cardiovascular conditions or diabetic retinopathy, and individuals with renal impairment face heightened risk and require closer monitoring

For example, patients can be advised to report persistent upper abdominal pain, fever, or jaundice

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Proc Natl Acad Sci U S A 98(6):30683073 Sucher AJ, Chahine EB, Balcer HE (2009) Echinocandins: the newest class of antifungals