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And all of us (who have obesity) have done this." "You have your limit
The clearest answer to date comes from a Phase 2 trial published in the New England Journal of Medicine in 2023, which reported 24.2% weight loss after 48 weeks at the highest dose in 338 adults with obesity but no other complications
Starting low reduces side effects
Bottom Line on Effectiveness: Tirzepatide Alternatives: Mounjaro, Zepbound, and properly compounded tirzepatide all produce 15-22% average weight loss Choose based on cost, availability, and conveniencenot effectiveness concerns Semaglutide Alternatives: Wegovy, Ozempic, and properly compounded semaglutide all produce 10-15% average weight loss Slightly less potent than tirzepatide but still highly effective Best value for weight loss medication The active ingredient determines effectiveness, not the brand name on the label
