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Weighted gene co-expression network analysis (WGCNA) identified genotype-driven, rather than treatment-driven, gene modules, highlighting distinct transcriptional architectures between WT and KO animals
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10,33 With regard to the secondary outcome of HF hospitalisation, the results were neutral, with LEADER showing a non-significant relative risk reduction (RRR) of 13% with liraglutide compared with placebo and SUSTAIN-6 showing no significant difference between the semaglutide and placebo treatment groups
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