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Ethics declarations Ethics approval and consent to participate All animal experiments in this study were carried out in conformity with the Guidelines for the Use and Care of Laboratory Animals of the National Institutes of Health and were approved by the Institutional Animal Care and Use Committee (IACUC) of Nanjing Medical University (IACUC-2306028)

Understanding why these FDA-approved GLP-1 receptor agonists may not work as expected requires examining multiple factorsfrom medication dosing and administration technique to underlying medical conditions and lifestyle behaviors

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