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For instance, the co-administration of tanshinone and polyphenol extract contributed to an increase in the area under the plasma concentration-time curve and a decrease in the total plasma clearance of SalB ( SalB has a synergistic effect that inhibits CD62p, a molecular marker of platelet activation and extends SalB s half-life by preventing the liver metabolizing enzyme catechol-O-methyltransferase (COMT) from being active ( SalB also raises plasma levodopa levels after extended usage and prevents levodopa from being methylated via COMT
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