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Research has found: People with premature greying often have significantly lower B12 levels than those without Higher rates of premature greying occur in those with pernicious anaemia Some case reports document reversal of grey hair following B12 supplementation B12 is thought to play a role in melanin production the pigment that gives hair its colour

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NAD+/NADH ratio assays, SIRT1 activity assays, and mitochondrial respiration measurements (such as oxygen consumption rate via extracellular flux analysis) are standard methods for studying this combination's proposed effects in cell-based models, typically comparing single-compound and combined-compound treatment conditions against untreated controls

doi:10.3109/15563659309000395

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