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Hydroxocobalamin is classified as Pregnancy Category C in the United States, indicating that risk to the fetus cannot be ruled out in the absence of definitive human data

It is typically administered by a healthcare professional in a clinic or hospital, but in some situations, patients may need to administer this medication in the home environment

B12 may accelerate red blood cell production in ways that may be harmful in this condition Use during pregnancy or breastfeeding should occur only if a licensed healthcare provider determines that potential benefits outweigh potential risks

Many change with age

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