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Biochim Biophys Acta 1801, 924929

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Kelek SE, Afar E, Akay G, Danman B, Aslan MJF, Toxicology C

Upon receptor binding, IGF1R undergoes autophosphorylation, initiating downstream signaling pathways, including: Phosphoinositide 3-kinase (PI3K)/Akt pathway Mitogen-activated protein kinase (MAPK) pathway These pathways are associated with intracellular signal transduction processes, including regulation of gene expression, protein translation, and cellular signaling dynamics at the molecular level