Hereditärer Katarakt (HSF4) - Australian Shepherd Diversität The disease typically starts before

The disease typically starts before 10 months of age

Severity of clinical signs vary

often accompanied with high fever

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Dominant normal E allele allows production of eumelanin therefore

Hereditärer Katarakt (HSF4) - Australian Shepherd Diversität The disease typically starts beforeCataract is one of the most common hereditary problems in Australian Shepherds and certainly the most common heritable eye disease of this breed. Typical clinical sign is opacity of the crystalline lens which leads to blindness. Primary inherited form of the disease is found in around 100 dog breeds, but despite its frequency the genetic basis is poorly understood. To date only HSF4 gene was associated with hereditary cataracts in dogs and is also