Thrombopathie - Landseer Mischling Shaking puppy syndrome (SPS) or

Shaking puppy syndrome (SPS) or hypomyelination syndrome (HS) is a disease characterized by an abnormally low amount of myelination or its absence in the axons of the central nervous system (CNS)

and signs collectively known as cretinism

tremor in the trunk of the body

Disproportionate dwarfism is a hereditary autosomal recessive disease that belongs to the group of skeletal dysplasias

because it arose in Collie breed and affected dogs have hypopigmented coats

Thrombopathie - Landseer Mischling Shaking puppy syndrome (SPS) orThrombopathia is an inherited platelet disorder. Affected dogs have abnormal platelet function because they are not able to stick together properly and therefore cannot form a clot. Dogs exhibit typical signs of platelet defects including bleeding from snouts, gingival bleeding, and petechiation. Other symptoms include weakness and rear limb paralysis secondary to spinal cord hemorrhage. The platelet defect is characterized by impaired or absent