Hypomyelinisierung / Shaking Puppy Syndrome (SPS) Hunde It is controlled by heterozygous

It is controlled by heterozygous mutations of merle locus and a modifier harlequin locus

Genetic diversity analysis (inbreeding and heterozygosity values)

resulting in the deterioration of the inner ear hair bundles and progressive hearing loss

seizures and movement difficulties

A 3-gene DNA test helps determine the likelihood of an individual dog developing DMS

Hypomyelinisierung / Shaking Puppy Syndrome (SPS) Hunde It is controlled by heterozygousShaking puppy syndrome (SPS) or hypomyelination syndrome (HS) is a disease characterized by an abnormally low amount of myelination or its absence in the axons of the central nervous system (CNS). SPS has been described in people and in dogs including Dalmatian, Bernese Mountain dog, Chow Chow and Weimaraner breeds. The cause of SPS is not known in all breeds. A causative mutation in the gene in Weimaraner breeds has been reported. In Weimaraner