D-Lokus (d3) CatCheck Laktatazidose

Laktatazidose

high sensitivity to light

because E allele is dominant eumelanin production is normal and expression of other loci can determine coat colour

B-Locus also affects colour of the nose

Betroffene Hunde zeigen klinische Anzeichen von Kehlkopflähmung oder Megaösophagus

D-Lokus (d3) CatCheck LaktatazidoseD Locus is responsible for coat colour dilution. Known mutations of the MLPH gene (melanophilin) are responsible for most cases of diluted colours. MLPH gene encodes a protein melanophilin, a key component in the hair and skin pigment formation. A mutation in the gene causes the improper distribution of melanosomes and coat colour dilution. It has an effect on the formation of black eumelanin as well as red yellow pheomelanin, though in lesser extent.