Lethale Lungenerkrankung (LAMP3) Einzelanalyse and progression of the disease

and progression of the disease is also very variable

die ausgeprägtere klinische Anzeichen haben und normalerweise im Alter von 3 Jahren eingeschläfert werden

Klinische Symptome bei betroffenen Welpen treten typischerweise im Alter von 6 bis 12 Wochen auf und schreiten rasch zu Status epilepticus und Tod oder Euthanasie fort

First obvious signs are evident at 12-14 days of age and progress thereafter

Examination material: oral mucosa swabs or 1-2 ml EDTA blood

Lethale Lungenerkrankung (LAMP3) Einzelanalyse and progression of the diseaseLethal lung disease is a neonatal genetic disease in Airedale Terrier associated with a mutation in LEMP3 gene. Affected puppies show interstitial lung disease due to abnormal surfactant biogenesis leading to lethal hypoxic respiratory distress and failure. The clinical symptoms appear early in life, usually within the first few weeks of a puppy's life. Affected puppies show signs of rapid or shallow breathing, lethargy, pneumonia as well as other