Kongenitale Ichthyose - Deutsche Dogge Searchterm frequent stumbling and muscle atrophy

frequent stumbling and muscle atrophy in the limbs

Severity of clinical signs vary

I-Locus causes so called »extreme dilution« of the pheomelanin

Genetic defect impairs protein physiological function in the eye

characterized by severe footpad hyperkeratosis

Kongenitale Ichthyose - Deutsche Dogge Searchterm frequent stumbling and muscle atrophyHereditary ichthyoses represent a heterogeneous group of skin cornification disorders characterized by hyperkeratosis and blistering or scaling of different severity levels. In Great Dane the disease is characterized by severe hyperkeratosis with a formation of strongly wrinkled, thickening and scaling skin, especially in the region of eyes and nose. The symptoms become evident right after birth and thus include dry and scaling skin, untidy appearance